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La résistance aux traitements pour la LMC est encore mal comprise. Or, voici que des chercheurs allemands ont identifié un mécanisme moléculaire de la LMC qui expliquerait cette résistance.
''Cancer researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have identified a molecular mechanism of chronic myeloid leukemia (CML) that causes the disease to progress and become resistant to drug treatment. In a current study, Dr. Marina Scheller (now at the University Hospital Hamburg-Eppendorf) and Professor Achim Leutz report that these two processes in CML – disease progression and drug resistance – are directly associated with each other due to crosstalk between two cellular signaling pathways. Their findings may lead to new strategies for developing combination treatments to halt the dreaded progression of the disease''
Extrait de Chronic Myeloid Leukemia: MDC Researchers Uncover Why the Disease Progresses and Becomes Resistant to Drug Treatment
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La protéine IRF8 inhibe la survie des cellules et celle-ci est souvent réduite dans les cellules leucémiques de la LMC.
"The protein, IRF8, inhibits the survival of cells and is often reduced in CML cells."
Pour en savoir un peu plus sur cette protéine, voir http://www.cmleukemia.com/interferon-re ... -irf8.html
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