New Route To Leukaemia Uncovered - septembre 2009
'....They discovered that if JAK2 is faulty, the cell's meticulously controlled message system 'short circuits'. As a result many genes are switched on and off inappropriately and a completely new cell signalling route by which leukaemia can develop is turned on.
The scientists found that the enzyme made by the JAK2 gene - is also located inside the cell nucleus and plays an important role to control how genetic information is used by the cell. Previously it was only known to be located on the inne cells - acting as a messenger between the outside of the cell and the cell's nucleus....'
http://www.medicalnewstoday.com/articles/165444.php
JAK2 phosphorylates histone H3Y41 and excludes HP1 from chromatin -27 September 2009
http://www.nature.com/nature/journal/va ... 08448.html
La Janus kinase 2
''La Janus kinase 2 (JAK2) est une protéine de type tyrosine kinase impliquée dans plusieurs voies de signalisation responsables principalement de la survie et de la prolifération cellulaire. JAK2 est lié aux récepteurs de la famille des cytokines, (ceux-ci pouvant être activé par des cytokines, des facteurs de croissance tels que l’EPO-R, TPO-R, GM-CSF-R, gamma IFN, GH-R, PRL-R. Des mutations au niveau du gène codant la protéine JAK2 sont impliqués dans l’apparition de certaines maladies myéloprolifératives.''
http://fr.wikipedia.org/wiki/Janus_kinase_2