La LMC chez l'enfant

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Leucémie myéloide chronique de l'enfant : l'imatinib est efficace comme chez l'adulte – Dr Isabelle Birden, mars 2006
'La leucémie myéloide chronique (L.M.C.) est très rare chez l’enfant. Elle atteint en effet un enfant sur un million avant 10 ans alors qu’elle touche 30 individus par million après 60 ans.
…. Après traitement par imatinib, le taux de rémission complète a été de 80 % quand les enfants étaient dans la première phase de la maladie……'
Extrait de http://www.fondation-groupama.com/sante ... /art_id-77

Deux études menées sur la LMC chez l’enfant - décembre 2006
http://www.cmlsource.ca/two_studies_cml ... php?lang=2

La FDA approuve l’imatinib chez l’enfant - décembre 2006
http://www.cmlsource.ca/imatinib_children.php?lang=2

Utilisation du dasatinib chez l’enfant et l’adolescent – septembre 2008
http://www.cmlsource.ca/dasatinib_children.php?lang=2

Leucémie
Leucémie myéloïde chronique (LMC), qui survient plus lentement que la LMA et risque moins d'entraver la production des autres types cellulaires. Les risques d'être atteint de la LMC varient de un sur un million, chez les enfants de moins de 10 ans, à un sur 10 000 pour les personnes de plus de 80 ans.
http://sante.canoe.com/condition_info_d ... ease_id=81

Comment aider mon enfant face à une leucémie
http://www.laurettefugain.org/diagnost.html

Les Leucémies - Mon combat pour la vie: Le cancer chez les enfants et les adolescents au Canada
http://www.phac-aspc.gc.ca/publicat/tbw ... r1-fra.php

Mon enfant souffre d'une leucémie
http://www.prochedemalade.com/j-accompa ... fant.shtml

Leucostase pulmonaire au cours d’une LMC de l’enfant – décembre 2006
http://www.santetropicale.com/club/pdf/1206/5312_10.pdf

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Stem cell transplantation extends lives of children with CML
Transplant News, Oct 14, 2003
http://findarticles.com/p/articles/mi_m ... n18617130/

What Are the Dangers of Bone Marrow Transplant in Children With CML?
http://www.ehow.com/about_5660067_dange ... -cml_.html

DASATINIB IN CHILDREN AND ADOLESCENTS WITH RELAPSED OR REFRACTORY LEUKEMIA: PRELIMINARY RESULTS OF THE CA180018 PHASE I/II STUDY FROM THE ITCC CONSORTIUM
13th Congress of the European Hematology Association, June 12-15, 2008
http://online.haematologica.org/eha13/b ... recid=2476

Imatinib Is Efficient but Has a Negative Impact On Growth in Children with Previously Untreated chronic Myelogenous Leukaemia (CML) in Early Chronic Phase (CP): Results of the French National Phase IV Trial
http://ash.confex.com/ash/2009/webprogr ... 18747.html

Child CML Talk – Forum de discussion
http://www.newcmldrug.com/Children/Default.asp

Children with CML (inclus un forum)
http://www.childrenwithcml.org.uk/home.asp?parent_id=1

Children with CMLChildren with CML (Forum de discussion)
http://www.cmlsupport.org.uk/?q=node/485

Registration of Children With CML and Treatment With Imatinib (CML-paed II)
http://clinicaltrials.gov/ct2/show/NCT00445822

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Les associations pour les enfants atteints de cancer ou de leucémie.

Leucan – Montréal (Canada)
http://www.leucan.qc.ca/fr/
http://www.leucan.qc.ca/cms/assets/docu ... ade-FR.pdf

La Fondation Centre de cancérologie Charles-Bruneau , Montréal (Canada)
http://www.charlesbruneau.qc.ca/fr/

La Société Française de Lutte contre les Cancers et Leucémies de l'Enfant et de l'Adolescent (SFCE) - France
http://www.sfpediatrie.com/fr/groupes-d ... nfant.html

Source Vive Aide aux enfants atteints de cancer ou de leucemie - France
http://www.source-vive.org/

ASSOCIATION D'AIDE AUX ENFANTS ATTEINTS DE LEUCEMIE OU DE CANCER DE LA REGION CENTRE VAL DE LOIRE (France)
http://www.sparadrap.org/Carnet-d-adres ... L-DE-LOIRE

La Fédération Enfants et Santé (France)
http://www.enfants-sante.asso.fr/

The Children's Leukemia Research Association - (New-York, État-Unis)
http://www.childrensleukemia.org/

Children's Leukemia Research Association, Niagara Falls (Ontario, Canada))
http://www.411.ca/business/Ontario/Niag ... 26834.html

The Children's Leukaemia Association, Cork City, Ireland
The Children's Leukaemia Association is a Cork based registered charity which supports and assists families whose children suffer form leukaemia
http://www.cla.ie/

Children's Leukemia Research Association(CLRA) New-York, États-Unis
http://www.allbusiness.com/membership-o ... 418-1.html

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Impact of the type of the BCR-ABL fusion transcript on the
molecular response in paediatric patients with chronic myeloid
leukemia
by Meinolf Suttorp, Christian Thiede, Josephine Tabea Tauer, Ursula Range,
Brigitte Schlegelberger, and Nils von Neuhoff
http://www.haematologica.org/cgi/reprin ... 9.019224v1

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Optic disc edema as a possible complication of Imatinib mesylate (Gleevec).
Kwon SI, Lee DH, Kim YJ.
Department of Ophthalmology, Hallym University Sacred Heart Hospital, Anyang,
Korea.
Ophthalmol. 2008 Jul-Aug;52(4):331-3. Epub 2008 Sep 5.

''BACKGROUND: Imatinib is effective for a variety of hematologic and
nonhematologic malignancies. Well-known ocular side effects are periorbital
edema, epiphora, extraocular muscle palsy, and blepharoconjunctivitis. However,
optic disc edema has not been reported as a complication of imatinib mesylate.
Herein, we describe a patient with chronic myeloid leukemia (CML) who developed
optic disc edema during treatment with imatinib.
CASE: A 14-year-old Korean girl was referred to ophthalmology for a 3-week
history of photopsia in both eyes. She had started taking imatinib daily 2 months previously for CML.
At the initial exam, slit lamp showed optic disc edema in both eyes, even though visual
acuity was 20/20 and other optic nerve function evaluations were within normal
limits. We recommended to the oncologist discontinuation of the imatinib
treatment.
OBSERVATIONS: When the patient was followed for 1 week after stopping
imatinib treatment, the frequency of photopsia decreased and the optic disc
edema improved. Because a second examination 3 weeks after discontinuation of
imatinib revealed much improved optic disc edema, she restarted the imatinib
treatment. No ocular side effects have been noted so far. CONCLUSIONS: Optic
disc edema should be considered one of the complications associated with
imatinib. We propose discontinuation of the treatment for a short period when
optic disc edema occurs.''
Extrait de http://www.springerlink.com/content/481708u25431r107/
Extrait de http://www.ncbi.nlm.nih.gov/pubmed/18773274

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Voir http://www.cmleukemia.com/children-with-cml.html

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Voir aussi Leucémie myéloide chronique de l'enfant : l'imatinib est efficace comme chez l'adulte mars 2006